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In this work we will deal with a serious disease that is the most common and inherited in the white race. We refer to Cystic Fibrosis or else to Inoculative Disease. The aim of the thesis is to deepen the characteristics of the disease and its physiotherapeutic intervention. After analysing the anatomical elements of the human body, we will proceed with the analysis of the disease, pathophysiology, symptoms and physiotherapeutic intervention both in the respiratory and the musculoskeletal system of the patients. Subsequently, detailed articles will follow to confirm that physiotherapy can be extremely helpful in improving the condition of patients as the ultimate goal is to preserve life. In the last chapter, our conclusions will be mentioned By reading the work you will be able to understand: What exactly is Cystic Fibrosis? The way of diagnosing the persons who are carriers and those who suffer from the disease. The physiotherapeutic intervention required. Modern techniques and their effectiveness. The prognosis of Disease in the present.