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Occupational burnout is defined as the psychological syndrome characterized by emotional exhaustion, depersonalization and lack of personal achievement. The purpose of this paper is to investigate the degree of professional exhaustion of Teachers working in public schools of Secondary Education and their impact on their general health status and hence their quality of life. The research sample consisted of 130 teachers working in public high schools, general and vocational high schools, mainly in the prefecture of Karditsa and the other prefectures of Thessaly. For the data collection a structured three-module questionnaire including demographic, individual and occupational characteristics was used, Maslach's professional burnout logging ( MBI ) and SF-36 Life Quality Assessment Questionnaire. In the Maslach Burnout Inventory questionnaire, teachers' statements show that the two Sessions of Occupational Exhaustion, Emotional Exhaustion and Depersonalization are at moderate scoring levels, while the third, Personal Achievement, is at a high level. There are also some statistically significant differences in the way the two sexes respond, as female educators show more signs of emotional exhaustion than men, while male sex seems to outweigh the sense of depersonalization. It is also noted that the position of the teacher in the school unit affects the occurrence of occupational burnout, as the deputy director of a secondary school unit experiences Emotional exhaustion more than a Director or a teacher who only teaches work. As to personal achievement and representation, it stands out the Managing Director. Moreover, the type of school seems to contribute to the occurrence of professional burnout, since from the answers of the research sample it was found that the teachers of the General Lyceums are experiencing to a greater extent their colleagues who work in high schools or vocational high schools. Concerning the results of the SF-36 questionnaire, the score for the eight (8) Health Indicators was very high (M = 60-100) compared to the average (M = 50),8 demonstrating the very good health and quality of life of the research sample. There was also a significant positive correlation ( p = 0.01) in the three sub-scales of the Maslach Burnout Inventory and the eight Health Indicators of the SF-36 Questionnaire. This implies the decisive impact of professional burnout on both the physical and mental health of teachers. The results of the survey have led to some findings, which are not generalizing, since they involve a small sample size, but some aspects of the subject are highlighted. Based on the findings, these teachers have some signs of emotional exhaustion, but in general the professional exhaustion they experience is low, with no significant impact on their mental and physical health. This results in their increased quality of life, which helps them to perform their professional role daily with liveliness and offer