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Zoonoses can cause a major problem in the production of animal products, including milk, meat and skins, but at the same time poses a threat to public health affecting the human population. This thesis analyzes three major infectious diseases, brucellosis, tuberculosis and bovine lumpy skin disease, indicating their important role in livestock, economy and public health. Brucellosis is a serious infectious disease affecting bovine, ovine and caprine animals and humans. It is known by various names such as Malta or Undulant fever and is of great importance for livestock as well as for public health as it is one of the most common occupational diseases for animal breeders. The transmission of the disease is through the genital and respiratory system and by contact of the mucous membranes and the blood of infected and healthy animals but also humans. The diagnosis of the Brucella bacterium causing the disease occurs by isolation from the tissues of the infected animal or by detecting its genetic material in the test specimens. In addition, it is based on techniques for the detection of produced antibodies. The treatment of the disease is based on the removal and killing of infected farmed animals, whereas in humans, usually antibiotics are combined. Tuberculosis is an important zoonotic disease which causes a reduction in dairy production and deaths in infected animals, while in countries where there are not appropriate measures, the transmission from the animals to the human is easy. Transmission of the bacteria causing the disease occurs by contact with infected animals and inhalation of airborne bacteria while pasteurization of milk plays a very important role in limiting the transmission of the disease. The diagnosis can be done by tuberculin skin test and tissue or sample culture in various media while the γ interferon method has been recently used. For humans there is a vaccine available and the limitation of the disease is based on the isolation and killing of infected animals in the farms. Lumpy skin disease is a viral disease that affects cattle and has a huge economic impact on livestock farming. It is a disease that is endemic in most African countries, while in recent years it has also been transmitted to Asia and Europe, and since 2015 cases are reported in the Greek territory as well. The diagnosis of the disease is based on the molecular detection of the LSDV genome and on the clinical symptoms of the affected animals. The development of methods to deal with it is imperative because of its increasing incidence in our country and its continued transmission to other countries. There are programs for the eradication of these three infectious diseases in Greece, aiming to the reduction of the frequency of the affected animals but also to the prevention of spreading and the protection of the livestock and the public health. In the present thesis are presented data on the incidence of infectious diseases of brucellosis and tuberculosis in the Pentalofos area of Thessaloniki, data from samples of the last 4 years (2015-2018), while for nodular dermatitis the animals are vaccinated in the area to limit the transmission of the disease.