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The present master thesis is a pilot study with the central subject of the correlation between clinical and epidemiological characteristics of adolescents with idiopathic scoliosis and their quality of life. The purpose of the research is to investigate the existence of relationships between the epidemiological characteristics of adolescents 10 to 18 years old, with idiopathic scoliosis, with their quality of life as it comes from the ISYQOL questionnaire. By identifying the factors that affect QOL and even worsen it, therapists will now be able to design an individualized rehabilitation program for each patient, taking appropriate measures to prevent the occurrence of psychosocial problems. Statistical tables of frequencies and relative frequencies, bar graphs and pies were used for the analysis of qualitative variables, while histograms of frequencies and relative frequencies as well as position and dispersion measures were used for the analysis of quantitative variables. Finally, the correlation coefficients (Spearman / Exact fisher test) and non-parametric tests (Mann-Whitney / Kruskal-Wallis) were used to investigate correlations. The results of the research showed that the use of brace negatively affects the QOL of adolescents, as well as the duration of treatment with a brace and the type of brace used. Also, it was found that boys have better QOL than girls, while those who have a family history of scoliosis and participate in extracurricular activities have better QOL than those who do not have a history of scoliosis and some extracurricular activity. Regarding BMI and the number of curves, they were not found to affect QOL. Other factors that appear to affect QOL are the severity of the scoliosis, the presence of double or single lumps, and the type of curves. A positive correlation with QOL was also seen in the age of diagnosis, height and months of treatment with Schroth exercises, while a negative correlation was found in age, weight, lump size and scoliosis curve size. Finally, it was found that the fear of worsening the back problem is associated with the fear of discomfort in adulthood and the feeling that the situation they are experiencing is "very difficult", with the fear that despite the efforts the situation will not improve.