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Background: The proportion of preterm infants is quite high according to the WHO and the combination of factors during and after pregnancy increases the risk of newborns having motor, cognitive and behavioral disorders. With the risk of neurodevelopmental delay, the referral of neonates for physical therapy is well established. Early physical therapy intervention can improve the baby's quality of life. Aim: The purpose of the study was to investigate how the evaluation can help the pediatric physiotherapist in formulating a treatment plan for a premature newborn. How the early intervention of the pediatric physiotherapist can improve the psychomotor development and quality of life of the newborn and finally to investigate what other factors affect the assessment and early intervention plan. Method: In order to conduct the case study, there was was collaboration with the Neonatal Intensive Care Unit (NICU) of G.N. Hippocrate, Thessaloniki. One preterm neonate was born who met the study inclusion criteria. The duration of the study was five months, the first two of which were in the ICU and then the treatment and measurements continued for three months in a pediatric clinic. The AIMS scale was used and the reflexes were recorded as well as the biometric characteristics of the newborn. Results: There was an improvement in the growth of the preterm infant in the NICU, which continued after discharge. The weight, length and head circumference approached the normal limits of neonates, with the data being statistically significant. from the monthly reflex assessment there appears to be a delay attributed to WS syndrome. The motor development assessment showed a statistically significant improvement at the end of the measurements. Conclusions - suggestions: The timely physiotherapy intervention, the application of reliable assessment tools in combination with the appropriate information of the parents, and the interdisciplinary cooperation of the health workers played an important role in improving the quality of life of the newborn. However, more in-depth studies are required.