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Introduction: Sarcopenia is a pathological condition that occurs in older people, while its possibility of appearance increases with age. Various diseases have been associated from time to time in many studies as being related to the appearance of sarcopenia. Many times this is a two-way relationship, since the disease can trigger the appearance of sarcopenia, while the progression of the disease is also affected by its consequences. Progressive loss of muscle mass and patient function appears to affect people with knee osteoarthritis. However, there are not many studies proving this hypothesis. Purpose: The present study aims to assess the relationship between sarcopenia and knee osteoarthritis and investigate if the loss of muscle mass and function affects the recovery in patients undergoing total knee arthroplasty. Methodology: The study material consists of 20 patients with osteoarthritis, who came to the hospital for total knee arthroplasty from November 2021 to April 2022. The patients were evaluated for sarcopenia according to the EWGSOP2 criteria, after measurements were made for muscle strength with a hand-held dynamometer and lean muscle mass was calculated based on bioelectrical impedance (BIA) liposuction. Thus, patients were categorized into two groups, sarcopenic and non-sarcopenic. The two groups were asked to complete the KOOS SCORE questionnaire, in order to evaluate the condition of their knee in two phases, before surgery and 3 months after. Results: The two groups did not show a statistically significant difference in muscle strength measurements. However, the lean mass indices, ALM and ALM/height2 had significant differences, since the sarcopenic group showed a reduced lean mass. Sarcopenic patients showed a smaller increase in the KOOS SCORE score compared to non-sarcopenic patients, but without a statistically significant difference. The score increased for both teams, with the time factor playing a greater role than the team. Conclusions: Both the sarcopenic group and the control group did not show significant differences between them in their scores for the assessment of the affected limb in any of the two phases of completing the questionnaire.