Eureka! Institutional Repository

Blood disorder diseases (BDDs) are very common all over the world, owing to hematopoietic system malfunction. Among non-treated BDDs, thalassemia, sickle cell anemia and G6P-d deficiency are most widely known as pro-oxidant mutations and possess elevated oxidative stress micro-environments. Τhe potential of medicines in nanoscale raises many hopes to address unmet medical needs, as defined recently by the WHO in its report. The object of this graduation thesis is the study of blood, various hematological disorders and compatibility with cerium doped nanoparticles. Nanomedicine employs various combinations of nanomaterials and molecules towards their application for the therapy of different disorders. Previous studies have developed and applied ceria-based materials for biomedical applications indicating cerium based nanoparticles as potent redox modulators and drug delivery agents. Considering, Ce-NPs as promising candidates for biomedical applications, the blood compatibility of such materials was investigated in various BDDs, where Reactive Oxygen Species (ROS) imbalances contribute to disease progression.