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The paper aims to investigate the impact of depression and management of the disease on the quality of life of patients undergoing classic and prolonged dialysis. This is a comparative study of patients with and without diabetes mellitus who undergo classic and prolonged hemodialysis in the Dialysis Unit of Pella in Skydra, Pella. The research tool of the study consists of a questionnaire with the demographic data (gender, age, family and professional status, educational level), clinical parameters (duration and type of primary disease, duration of diabetes mellitus, type of antidiabetic treatment, dialysis adequacy), the short form of the World Health Organization's Quality of Life Instrument, the Hospital Anxiety and Depression Scale, and the Self-Efficacy for Managing Chronic Disease Scale. Prolonged hemodialysis lasting for 5 to 7 hours is a new pioneering trend in nephrology care. The results of the study have shown that patients on hemodialysis less than three years, experience depression and anxiety especially those in classical hemodialysis and men. Also, the results showed that the quality of life of respondents is affected by hemodialysis. The type of hemodialysis and the existence of diabetes also affect the level of depression and anxiety. Correspondingly, patients with DM reported particularly higher anxiety (8,17, ± 4,27) versus non-diabetics (5,96, ± 3,95), as well as higher depression levels (9,14, ± 3.96) compared to non-diabetics (6.32 ± 3.87) (p=.014 and p=.001, respectively). In particular, there appears to be a statistically significant linear correlation of sex with the anxiety and depression scale (p = 0.024 and p = 0.015, respectively) and the educational level with the depression scale (p = 0.025). The collaboration of the xi interdisciplinary nephrology team (nephrologist, renal nurse, psychologist, social worker and dietitian) is imperative in achieving patient's smooth adaptation to the new reality of renal disease and ensuring a satisfactory level of quality of life.