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Introduction: Juvenile diabetes mellitus or type 1 is a chronic illness that disrupts family functioning and causes anxiety for both parents and children by affecting their physical and mental health. Purpose: Purpose of this study was to evaluate the effectiveness of a physiotherapeutic stress management program(active therapeutic exercise, pressure therapy, diaphragmatic breathing and progressive muscle relaxation) in reducing stress symptoms. Material / Method :. This is a pilot, randomized controlled trial that was held at the Hippocratic Hospital of Thessaloniki. A total of 107 subjects, an intervention group of 26 children (7 - 17 years old) and 28 parents (n = 54) and a control group of 28 children and 25 parents (n = 53) participated. The measurement tools included questionnaires for the assessment of perceived stress, perception of health, quality of life and depression. The value of glycosylated hemoglobin and hypoglycemic episodes of children was measured. Results: After 12 weeks of intervention, the trait anxiety of children was reduced about 5,2 units (p = 0,001) and the state anxiety about 4,4 (p = 0,000) Significant difference was not observed in the glycosylated hemoglobin levels between the two groups, but was observed a significant reduction in hypoglycemic episodes of the class (42%, p = 0,028), with an average reduction of 2.25 hypoglycaemic episodes in the children of the intervention group. The symptoms of depression, anxiety and stress in parents of intervention group were significantly reduced about 2,94 units (p = 0.010), 1.89 (p = 0.019), 2.14 (p = 0.048), respectively. Conclusions: The physiotherapy program was associated with changes in the physical and psychological symptoms of children with TD1 and their parents. It turned out to have had a positive impact on depression and stress and a significant improvement in their quality of life. Similar future research on long-term benefits of a physiotherapeutic intervention program is warranted for more objective outcomes.